Comparison of ivermectin and extended-release ...

Authors

• C. A. Clark

  Jiayi Pharmaceutical Product Page

  Armstrong Research and Demonstration Farm, Iowa State University, Lewis, IA

• P. J. Gunn

  Department of Animal Science, Iowa State University, Ames, IA

Keywords:

cattle, fecal egg count, grazing, ostertagia, parasite, deworming, avermectin nematicides, avermectins, beef cattle, body condition, carcass composition, carcass quality, carcass weight, carcass yield, eprinomectin, faecal egg count, feedlots, fenbendazole, ivermectin, liveweight, liveweight gain, summer, parasites, helminths, helminthoses, parasitoses, nematode infections, animal parasitic nematodes

Abstract

The effect of deworming beef heifers with either ivermectin or extended-release eprinomectin on performance and carcass characteristics of stocker and feedlot cattle was assessed. Sixty Angus heifers (610 +/- 50 lb initial body weight; 277 +/- 23 kg) were blocked by body condition score and body weight, and allotted to 1 of 2 injectable deworming treatments after grazing summer pasture for 35 days: (1) ivermectin (IVM) or (2) extended-release eprinomectin (ERE). After 63 days grazing, heifers were placed in a feedlot and fed a finishing ration for 150 days. Heifers were stratified by BW within grazing treatment and allotted to receive ivermectin (dewormed; DWRM) or no treatment during processing (NO) at feedlot entry. Although fecal egg counts did not differ at treatment initiation, egg counts were greater in the IVM group (5.138 eggs per gram) than in the ERE group (0.073 EPG) at the end of the grazing period (P less than 0.01). Heifers in the ERE group had greater average daily gain and greater body weight change (P=0.01) during the grazing period. There were no differences in feedlot performance or carcass characteristics (P greater than or equal to 0.09) between treatment groups. Based on this study, there may be no benefit to deworming at feedlot arrival when cattle are effectively managed to minimize internal parasite infection during the grazing period. However, even at extremely low levels of infection during grazing, parasites can significantly impact performance.

A Comparative Study on the Effects of Eprinomectin and Ivermectin on Plasma Antioxidant Level and Lipid Peroxidation in Cows

Copy For Citation

BİLGİLİ A., Kart A., ÇİĞREMİŞ Y., Hanedan B., ERDAĞ D.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.15, no.2, pp.287-292, (SCI-Expanded)

• Publication Type:

  Article / Article

• Volume:

  15

  The company is the world’s best Eprinomectin for Veterinary Use supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.

  Issue:

  2

• Publication Date:

• Journal Name:

  KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI

• Journal Indexes:

  Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)

• Page Numbers:

  pp.287-292

• Keywords:

  Eprinomectin, Ivermectin, MDA, GSH, TOPICAL ENDECTOCIDE, OXIDATIVE STRESS, CATTLE, PHARMACOKINETICS, TRANSFERASE, TOXICITY, INCREASE

• Ankara University Affiliated:

  Yes

Abstract

Avermectins including Ivermectin and Eprinomectin are broad spectrum endectocides. These drugs are considered to have no serious adverse effects at therapeutic range. However, use of avermectins in overdose in some animal species and at the therapeutic range in humans could result in some adverse effects including mainly nervous system effects and some general symptoms. This study was aimed to investigate effects of Eprinomectin and Ivermectin on plasma malondialdehyde (MDA) and glutathione (GSH) levels in lactating cow. Ten Holstein breed lactating dairy cows were divided into 2 groups. Before the application of drugs, blood samples were collected from the jugular vein in each group at 0 hour as control, and then Group 1 and 2 received a single pour-on application of Ivermectin (0.5 mg/kg body weight) and Eprinomectin (0.5 mg/kg body weight), respectively. Blood samples were then collected again from the jugular vein at timed-intervals (at 1, 4, 8, 24 and 36 hours and on 2, 3, 4, 5, 6, 8, 10, 12, 15, 20 and 25th days) to measure plasma MDA and GSH concentrations. Eprinomectin and Ivermectin treatment caused a transient decrease in GSH levels which is followed by transient increase (P < 0.05). However, no difference was observed in MDA levels at all sampling points following the Eprinomectin and Ivermectin treatment compared to control samples (P > 0.05). It was concluded that Eprinomectin and Ivermectin cause decreased GSH concentrations without alterations in MDA level leading to a decrease in the defense mechanism against oxidative stress although the decrease is not enough to cause lipid peroxidation.

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